Description and function of guanidine hydrochloride
Jun 07, 2024| Description and function of guanidine hydrochloride
Basic description:
Guanidine hydrochloride is an organic substance with the chemical formula CH6ClN3 and is a white or yellowish lump. Used as an intermediate in medicine, pesticides, dyes and other organic compounds, it is an important raw material for the manufacture of sulfonamides and folic acid, and can also be used as an antistatic agent for synthetic fibers.
Basic properties:
White or yellowish mass, melting point (° C) : 181-183, soluble in water, methanol, ethanol, almost insoluble in acetone, benzene, and ether.
Common applications:
1. It can be used as intermediates in medicine, pesticides, dyes and other organic synthesis. It is an intermediate in the manufacture of sulfadiazine, sulfadimethymidine and other sulfadiamine drugs.
2. It is used to synthesize folic acid, an anti-anemia drug. It can also be used as an antistatic agent for synthetic fibers.
3. It can also be used as protein denaturant.
4. As a strong denaturant in the experiment of extracting total RNA from cells. The guanidine hydrochloride solution can dissolve the protein, resulting in the destruction of the cell structure, the destruction of the secondary structure of the nuclear protein, and the dissociation from the nucleic acid, in addition, the RNA enzyme can be inactivated by reducing agents such as guanidine hydrochloride.